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Year Number of Results
1976 2
1978 2
1980 1
1982 3
1983 1
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1987 2
1989 2
1990 1
1991 6
1992 2
1993 2
1994 6
1995 8
1996 10
1997 6
1998 10
1999 12
2000 16
2001 13
2002 19
2003 30
2004 22
2005 39
2006 35
2007 35
2008 85
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2013 68
2014 90
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2016 133
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2024 128

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AdMSC-derived exosomes alleviate acute lung injury via transferring mitochondrial component to improve homeostasis of alveolar macrophages.
Xia L, Zhang C, Lv N, Liang Z, Ma T, Cheng H, Xia Y, Shi L. Xia L, et al. Theranostics. 2022 Mar 21;12(6):2928-2947. doi: 10.7150/thno.69533. eCollection 2022. Theranostics. 2022. PMID: 35401830 Free PMC article.
Rationale: Aberrant activation of macrophages with mitochondria dismiss was proved to be associated with pathogenesis of ALI (acute lung injury). Exosomes from adipose-derived mesenchymal stem cells (AdMSC-Exos) have been distinguished by their low immunogenicity, lack of …
Rationale: Aberrant activation of macrophages with mitochondria dismiss was proved to be associated with pathogenesis of ALI (acute l …
Identification and validation of ferroptosis-related genes in lipopolysaccharide-induced acute lung injury.
Wang S, Song Y, Xu F, Liu H, Shen Y, Hu L, Fu Y, Zhu L. Wang S, et al. Cell Signal. 2023 Aug;108:110698. doi: 10.1016/j.cellsig.2023.110698. Epub 2023 May 5. Cell Signal. 2023. PMID: 37149072
METHODS: Murine ALI model was established via intratracheal instillation with LPS and confirmed by H&E staining and transmission electronic microscopy (TEM). ...This study may be helpful to expand our understanding of ALI and provide some potential …
METHODS: Murine ALI model was established via intratracheal instillation with LPS and confirmed by H&E staining and …
SIRT1-mediated p53 deacetylation inhibits ferroptosis and alleviates heat stress-induced lung epithelial cells injury.
Chen H, Lin X, Yi X, Liu X, Yu R, Fan W, Ling Y, Liu Y, Xie W. Chen H, et al. Int J Hyperthermia. 2022;39(1):977-986. doi: 10.1080/02656736.2022.2094476. Int J Hyperthermia. 2022. PMID: 35853732 Free article.
However, the mechanism underlying ALI following HS remains unclear. METHOD: To investigate whether ferroptosis is involved in HS-ALI. We established a HS model of mice and mouse lung epithelial-2 cells (MLE-2). The severity of lung injury was measured by H&am …
However, the mechanism underlying ALI following HS remains unclear. METHOD: To investigate whether ferroptosis is involved in HS-A …
BMSC-Derived Exosomes Ameliorate LPS-Induced Acute Lung Injury by miR-384-5p-Controlled Alveolar Macrophage Autophagy.
Liu X, Gao C, Wang Y, Niu L, Jiang S, Pan S. Liu X, et al. Oxid Med Cell Longev. 2021 Jun 13;2021:9973457. doi: 10.1155/2021/9973457. eCollection 2021. Oxid Med Cell Longev. 2021. PMID: 34234888 Free PMC article.
Here, we investigated the BMSC-derived exosomal microRNAs (miRNAs) on effecting lipopolysaccharide- (LPS-) induced ALI and its mechanism. In vitro, rat alveolar macrophages were treated with or without exosomes in the presence of 10 mug/ml LPS for 24 h. ...The lung …
Here, we investigated the BMSC-derived exosomal microRNAs (miRNAs) on effecting lipopolysaccharide- (LPS-) induced ALI and its mechan …
Combination of pseudoephedrine and emodin ameliorates LPS-induced acute lung injury by regulating macrophage M1/M2 polarization through the VIP/cAMP/PKA pathway.
Wang WB, Li JT, Hui Y, Shi J, Wang XY, Yan SG. Wang WB, et al. Chin Med. 2022 Feb 5;17(1):19. doi: 10.1186/s13020-021-00562-8. Chin Med. 2022. PMID: 35123524 Free PMC article.
The rats in the LPS and treatment groups were then injected intraperitoneally with LPS (7.5 mg/kg) to induce ALI. After being treated with pseudoephedrine and emodin for 12 h, all animals were sacrifice. Anal temperatures were taken on an hourly basis for 8 h …
The rats in the LPS and treatment groups were then injected intraperitoneally with LPS (7.5 mg/kg) to induce ALI. After being treated …
Emodin Attenuates LPS-Induced Acute Lung Injury by Inhibiting NLRP3 Inflammasome-Dependent Pyroptosis Signaling Pathway In vitro and In vivo.
Liu Y, Shang L, Zhou J, Pan G, Zhou F, Yang S. Liu Y, et al. Inflammation. 2022 Apr;45(2):753-767. doi: 10.1007/s10753-021-01581-1. Epub 2021 Nov 17. Inflammation. 2022. PMID: 34787801 Free PMC article.
This study investigated the protective effects and potential mechanisms of emodin on lipopolysaccharide (LPS)-induced acute lung injury (ALI) in vitro and in vivo. In vivo, we designed an LPS-induced ALI rat model. ...The degree of pathological injury in lung tissue …
This study investigated the protective effects and potential mechanisms of emodin on lipopolysaccharide (LPS)-induced acute lung injury ( …
Oridonin protects LPS-induced acute lung injury by modulating Nrf2-mediated oxidative stress and Nrf2-independent NLRP3 and NF-κB pathways.
Yang H, Lv H, Li H, Ci X, Peng L. Yang H, et al. Cell Commun Signal. 2019 Jun 11;17(1):62. doi: 10.1186/s12964-019-0366-y. Cell Commun Signal. 2019. PMID: 31186013 Free PMC article.
Our aim was to study whether the anti-inflammatory and antioxidant effects of Ori on LPS-induced ALI were mediated by Nrf2. METHODS: MTT assays, Western blotting analysis, a mouse model, and hematoxylin-eosin (H & E) staining were employed to explore the …
Our aim was to study whether the anti-inflammatory and antioxidant effects of Ori on LPS-induced ALI were mediated by Nrf2. METHODS: …
Inhibition of inflammasome activation via sphingolipid pathway in acute lung injury by Huanglian Jiedu decoction: An integrative pharmacology approach.
Chen Y, Peng M, Li W, Zhao M, Cao X, Li C, Zhang H, Yang M, Liang L, Yue Y, Xia T, Zhong R, Wang Y, Shu Z. Chen Y, et al. Phytomedicine. 2022 Dec;107:154469. doi: 10.1016/j.phymed.2022.154469. Epub 2022 Sep 20. Phytomedicine. 2022. PMID: 36202056
Network pharmacology predictd the active components of HLD in ALI. Lung tissues were subjected to perform Hematoxylin-eosin (H&E) staining, metabolomics, and transcriptomics. ...Therefore, HLD and its active components can be used to develop new therapies …
Network pharmacology predictd the active components of HLD in ALI. Lung tissues were subjected to perform Hematoxylin-eosin (H …
Honokiol alleviates LPS-induced acute lung injury by inhibiting NLRP3 inflammasome-mediated pyroptosis via Nrf2 activation in vitro and in vivo.
Liu Y, Zhou J, Luo Y, Li J, Shang L, Zhou F, Yang S. Liu Y, et al. Chin Med. 2021 Nov 29;16(1):127. doi: 10.1186/s13020-021-00541-z. Chin Med. 2021. PMID: 34844623 Free PMC article.
The degree of pathological injury of lung tissue was evaluated by H&E staining. RESULTS: The results showed that HKL could alleviate oxidative stress and inflammatory responses by regulating the levels of MPO, MDA, SOD, IL-1beta, IL-18 in supernatant. ...Further …
The degree of pathological injury of lung tissue was evaluated by H&E staining. RESULTS: The results showed that HKL could …
Neutrophils disturb pulmonary microcirculation in sepsis-induced acute lung injury.
Park I, Kim M, Choe K, Song E, Seo H, Hwang Y, Ahn J, Lee SH, Lee JH, Jo YH, Kim K, Koh GY, Kim P. Park I, et al. Eur Respir J. 2019 Mar 28;53(3):1800786. doi: 10.1183/13993003.00786-2018. Print 2019 Mar. Eur Respir J. 2019. PMID: 30635296 Free PMC article.
This study aimed to investigate how the pulmonary microcirculation is distorted in sepsis-induced acute lung injury (ALI) and reveal the underlying cellular pathophysiologic mechanism.Using a custom-made intravital lung microscopic imaging system in a murine model of sepsi …
This study aimed to investigate how the pulmonary microcirculation is distorted in sepsis-induced acute lung injury (ALI) and reveal …
2,758 results